Propofol Versus Midazolam for Lower Gastrointestinal Endoscopy

Sherief Abd-Elsalam

Status and phase: Unknown; Phase 3

Conditions: Cirrhosis, Liver

Treatments: Drug: Midazolam; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03388151

Propofol colonoscopy

Details and patient eligibility

About

propofol versus use of midazolam as sedative agent in patients with liver cirrhosis presented for lower gastrointestinal endoscopy

Full description

Effect of use of propofol versus use of midazolam as sedative agent in patients with liver cirrhosis presented for lower gastrointestinal endoscopy, Randomised controlled trial.

Enrollment: 100 estimated patients

Sex: All

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Liver cirrhosis
• presented to colonoscopy

Exclusion criteria

• Encephalopathy
• Hypersensitivity
• Coagulopathy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Midazolam

Active Comparator group

Description:

Midazolam 3 mg i.v added to fentanyl 0.5 ug/kg till reaching satisfactory level of sedation

Treatment:

Drug: Midazolam

Propofol

Active Comparator group

Description:

Propofol 1 mg/kg i.v added to fentanyl 0.5 ug/kg i.v till reaching satisfactory level of sedation

Treatment:

Drug: Propofol