Propofol Versus Volatile Anesthesia in Post Operative Pain Management

NeuroTherapia, Inc.

Status: Terminated

Conditions: Postoperative Pain; Varicose Vein

Treatments: Drug: propofol; Drug: sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT00712517

42908

Details and patient eligibility

About

The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.

Full description

Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants will undergo a stripping operation for varicose veins
• Surgery will be performed by one physician only
• Written informed consent

Exclusion criteria

• Any contraindications to the proposed interventions
• Procedures done under regional anesthesia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

1

Active Comparator group

Description:

Patients will receive propofol anesthesia during varicose vein stripping surgery.

Treatment:

Drug: propofol

2

Active Comparator group

Description:

Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.

Treatment:

Drug: sevoflurane