Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury

Minia University

Status and phase: Unknown; Early Phase 1

Conditions: Traumatic Brain Injury

Treatments: Drug: Propranolol

Study type: Interventional

Funder types: Other

Identifiers

NCT04833218

389:1/2020

Details and patient eligibility

About

evaluation of the effect of Propranolol versus propranolol and clonidine on decreasing sympathetic hyperactivity after moderate traumatic brain injury

Full description

measuring catecholamine levels after moderate traumatic brain injury after giving propranolol and clonidine

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• GCS on admission between 9 and 12 age 18 up to 60 years both sexes

Exclusion criteria

• history of heart disease, cardiac arrhythmia and myocardial infarction diagnosis ofpreexisting brain dysfunction. impending brain herniation and craniotomy diagnosis of spinal cord injuries. diagnisis of severe liver and renal disease current use of beta blocker and or alpha agonist current using of intravenous vasopressor contraindication to enteral feeding and can not swallow pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups

propranolol group

Active Comparator group

Description:

we will give propranolol 40 milligram tablet twice daily in orogastric or nasogastric tube

Treatment:

Drug: Propranolol

propranolol clonidine

Active Comparator group

Description:

we will give propranolol 20 milligram tablet twice daily and clonidine 150 microgram tablet twice daily in orogatric or nasogastric tube

Treatment:

Drug: Propranolol

control group

No Intervention group

Description:

we will give conventional treatment, no propranolol nor clonidine