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Proprioception and Sensorimotor Control in Hereditary Sensory and Autonomic Neuropathy

NYU Langone Health logo

NYU Langone Health

Status

Completed

Conditions

Atunomic Neuropathy

Treatments

Other: kinesiology tape around the hip, knee and ankle joints
Other: No kinesiology tape around the hip, knee and ankle joints

Study type

Interventional

Funder types

Other

Identifiers

NCT02876939
16-00530

Details and patient eligibility

About

This project comprises three sets of physiological studies - testing eight specific hypotheses - that will contribute new knowledge on proprioception and motor control in a genetic disorder that affects specific components of the sensory nervous system.

I: To investigate the neurophysiological basis for disturbed motor control in Hereditary sensory and autonomic neuropathy (HSAN) III II: To investigate the effects of enhancing cutaneous feedback on motor control in HSAN III III: To investigate the cortical representation of proprioceptive inputs in HSAN III

Full description

HSAN III patients (n=15) and healthy control subjects (n=15) will lay supine on an MRI bed and a tungsten microelectrode inserted percutaneously into a muscle or cutaneous fascicle of the right common peroneal nerve at the fibular head, according to standard techniques employed by Prof Macefield. Neural activity will be acquired, RMS-processed (200 ms) and analysed on computer. The subject's head will be tightly enclosed in a standard clinical 32-channel SENSE head coil and headphones will be provided to minimize noise and to allow communication with the subject. The subject will be placed in the bore of a 3T whole-body scanner for 60-90 minutes.

Enrollment

16 patients

Sex

All

Ages

16 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Confirmed genetic diagnosis of HSAN III will be recruited from the Dysautonomia Center at NYU

Exclusion criteria

  • homeless
  • active drug or alcohol dependence
  • evidence of neurological disorder or diabetes
  • exposure to neurotoxic drugs that in the investigator's opinion may compromise results
  • Pregnant women

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

16 participants in 2 patient groups

HSAN III
Experimental group
Treatment:
Other: No kinesiology tape around the hip, knee and ankle joints
Other: kinesiology tape around the hip, knee and ankle joints
Control Subjects
Active Comparator group
Treatment:
Other: No kinesiology tape around the hip, knee and ankle joints
Other: kinesiology tape around the hip, knee and ankle joints

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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