Proprioceptive Error Correction for Post-Stroke Upper Limb Rehabilitation

Sungkyunkwan University

Status

Enrolling

Conditions

Ischemic Stroke

Proprioception

Treatments

Behavioral: Electrical stimulation cue

Behavioral: Visual stimulation cue

Behavioral: No cue

Study type

Interventional

Funder types

Other

Identifiers

NCT07156955

2025-06-075-001

Details and patient eligibility

About

The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients.

The human nervous system often receives mismatched information from vision and proprioception during upper limb control, resulting in conflicting sensory inputs that limit the effectiveness of motor learning. In other words, real-time sensory feedback - a critical component of motor learning in the nervous system - is not reliably delivered. Therefore, this study seeks to resolve sensory conflicts by providing additional sensory information through electrical stimulation, with the goal of dramatically improving the effectiveness of motor learning.

Enrollment

3 estimated patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosed with ischemic or hemorrhagic stroke
Stroke confirmed by CT or MRI
Stroke patients with proprioceptive sensory deficits
Chronic stroke patients with onset at least 3 months prior
Able to voluntarily flex and extend the elbow joint
Age 19 years or older
Provide written informed consent (participant or legal representative)

Exclusion criteria

Severe pain during elbow joint movement
Elbow joint contracture, spasticity, ataxia, musculoskeletal disorders, fractures, - non-healing ulcers, or open wounds
Progressive or unstable stroke
Presence of unilateral neglect
Coexisting severe neurological disorders
Major psychiatric disorders such as major depressive disorder, schizophrenia, bipolar disorder, or dementia Presence of a pacemaker

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

3 participants in 6 patient groups

Electrical stimulation cue first

Experimental group

Description:

Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order Electrical stimulation cue, Visual cue, and No cue or Electrical stimulation cue, No cue, and Visual cue.

Treatment:

Behavioral: No cue

Behavioral: Visual stimulation cue

Behavioral: Electrical stimulation cue

Visual stimulation cue first

Experimental group

Description:

Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: Visual cue, Electrical stimulation cue, and No cue, or Visual cue, No cue, and Electrical stimulation cue.

Treatment:

Behavioral: No cue

Behavioral: Visual stimulation cue

Behavioral: Electrical stimulation cue

No cue first

Experimental group

Description:

Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: No cue, Electrical stimulation cue, and Visual cue, or No cue, Visual cue, and Electrical stimulation cue.

Treatment:

Behavioral: No cue

Behavioral: Visual stimulation cue

Behavioral: Electrical stimulation cue

Only electrical stimulation cue

Experimental group

Description:

Patients undergo one types of interventions which is the Electrical stimulation cue.

Treatment:

Behavioral: Electrical stimulation cue

Only visual stimulation cue

Experimental group