Pros and Cons of Botulinum Injection Treatment in Cerebral Palsy

Marmara University

Status: Completed

Conditions: Botulinum Toxin; Cerebral Palsy

Treatments: Other: Qualitative interview

Study type: Observational

Funder types: Other

Identifiers

NCT04256187

09.2020.114

Details and patient eligibility

About

The aim of this study is to quantitatively record the opinions regarding the pros and cons of this treatment of the caregivers of children with cerebral palsy who had botulinum toxin applied in investigators' clinic.

Full description

Spasticity is defined as an increase in physiological resistance of the muscles associated with a lack of supraspinal inhibition against passive strain. It is a common and prohibitive problem associated with an increase in tendon reflex and tension reflex associated with upper motor neuron dysfunction. One of the most common problems in patients with CP.

Methods used in the treatment of spasticity; medical therapy, physical therapy, intrathecal baclofen pump, botulinum toxin injection, and orthopedic correction operations. However, botulinum toxin type-A (BTX-A) injections, which are applied to the muscles especially for localized spasticity, have become an effective adjuvant option that increases the effectiveness of classical methods and diversifies the treatment options.

BTX-A, which is basically a chemodenervation method; It is a treatment method that blocks the transmission of signal in the neuromuscular junction by preventing the release of acetylcholine vesicles into the presynaptic space. In spastic muscles, relaxation can be achieved by correct injection. Botulinum toxin type A has been shown to be an effective and safe treatment for children to reduce spasticity.

In Turkish society, there is no study evaluating the caregivers' experiences and opinions about botox treatments of patients with the diagnosis of cerebral palsy and limited studies in the literature are from countries with different sociodemographic features such as the United States and the United Kingdom. Although these patients have been receiving this treatment in investigators' center for years, there is no study in the literature that evaluates the plus and minus aspects of caregivers' experiences in this regard.

Enrollment: 21 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• To be the caregiver of a patient under 18 years old with cerebral palsy
• No attempt has been made to reduce spasticity such as botulinum toxin injection in the last 3 months.

Exclusion criteria

• Not knowing Turkish
• Refusing to participate in the study.

Trial design

21 participants in 1 patient group

Healthy group

Description:

Caregivers of children who treated with botulinum toxin.

Treatment:

Other: Qualitative interview