Prospective Analysis Into Development of Hypernatremia in Critically Ill Patients (HYPNIC II)

Catharina Hospital

Status

Unknown

Conditions

Hypernatremia

Critical Illness

Treatments

Other: Daily urine collection for biochemical analysis

Other: Subanalysis for comparison of 24hour urine collection versus spot-check measurements

Study type

Observational

Funder types

Other

Identifiers

NCT05085223

HYPNIC II

Details and patient eligibility

About

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and sodium balance or renal replacement therapy is lacking. The predecessor of this study was the HYPNIC trial which found that increased sodium load en decreased sodium excretion preceded hypernatremia development, but was lacking information on the first 48 hours, fluid balances were manually collected before a new data collection system was introduced and was suffering from substantial amounts of missing data and small population for trend analysis.

This study aims to provide better insight in the development and recovery of hypernatremia while paying attention to the limitations from the HYPNIC trial.

Enrollment

1,500 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria