Prospective Becker-Heart-Study (Becker-HS)

Karim WAHBI

Status: Unknown

Conditions: Heart Failure; Lef Ventricular Dysfunction; Dilated Cardiomyopathy

Treatments: Procedure: ECG, echocardiography, cardiac MRI, sera biomarkers

Study type: Observational

Funder types: Other

Identifiers

NCT02020954

Becker-Heart-Study

Details and patient eligibility

About

The purpose of this study is to determine whether electrocardiogram, echocardiography, cardiac MRI, sera biomarkers can improve early detection of myocardial involvement and clinical outcome.

Full description

A cohort of 100 patients with mutations in the dystrophin gene associated with Becker muscular dystrophy and/or dilated cardiomyopathy will be included (patients with Duchenne muscular dystrophy are excluded).

Patients with undergo at baseline the following workups: electrocardiogram, echocardiography, cardiac MRI, sera biomarkers measurement.

At 3 years and 5 years, patients will be investigated according to the same protocol and occurrence of cardiac adverse events in the meanwhile will be recorded.

Statistical analysis will assess correlations between cardiac phenotype and DMD mutations and prognostic value of cardiac investigations.

Enrollment: 100 estimated patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• mutation in the DMD gene
• Becker muscular dystrophy and/or dilated cardiomyopathy
• age>18 years
• affiliation to the French medical insurance

Exclusion criteria

• Duchenne muscular dystrophy
• Any other chronic disease that may be associated with heart disease

Trial design

100 participants in 1 patient group

Dystrophinopathy

Description:

Patients with mutations in the DMD gene and Becker muscular dystrophy and/or dilated cardiomyopathy

Treatment:

Procedure: ECG, echocardiography, cardiac MRI, sera biomarkers