Prospective Clinical Trial of Three Apical Sealing Materials

University of the Pacific

Status and phase: Completed; Phase 4

Conditions: Periapical Abscess

Treatments: Drug: EndoSequence; Drug: Biodentine; Drug: ProRoot MTA

Study type: Interventional

Funder types: Other

Identifiers

NCT04198298

20-60

Details and patient eligibility

About

This prospective comparative randomized clinical trial compares healing and bony regeneration in patients who received 1 of 3 different retrograde filling materials following microsurgical apicoectomies for the treatment of periapical lesions of endodontic origin.

Full description

A prospective comparative randomized clinical trial was designed to evaluate the healing and bony regeneration in patients who received 1 of 3 different retrograde filling materials (EndoSequence®, ProRoot® MTA, or Biodentine®) following microsurgical apicoectomies for the treatment of periapical lesions of endodontic origin.

Enrollment: 59 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult patients, American Society of Anesthesiologists (ASA) classification I and II
• Any tooth with a single chronic periapical lesion requiring apical microsurgery
• Informed consent signed prior to surgery

Exclusion criteria

• Background of drug/alcohol abuse
• Adjacent periapical lesion
• Periodontal disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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59 participants in 3 patient groups

Group 1 EndoSequence

Active Comparator group

Description:

The EndoSequence® retrograde sealing material was used to provide a biologic seal at the apex.

Treatment:

Drug: EndoSequence

Group 2 ProRoot MTA

Active Comparator group

Description:

The ProRoot® MTA retrograde sealing material was used to provide a biologic seal at the apex.

Treatment:

Drug: ProRoot MTA

Group 3 Biodentine

Active Comparator group

Description:

The Biodentine® retrograde sealing material was used to provide a biologic seal at the apex.

Treatment:

Drug: Biodentine