Prospective Cohort of Patients With Systemic Sclerosis at Brest University Hospital With Biobanking (SCLEROBREST)

Regional University Hospital Center (CHRU)

Status: Enrolling

Conditions: Systemic Sclerosis

Treatments: Other: Questionnaires on quality of life, pain and disability; Other: Blood samples; Other: Stool samples; Other: Skin biopsies; Other: Skin swab samples

Study type: Observational

Funder types: Other

Identifiers

NCT05532865

29BRC21.0258

Details and patient eligibility

About

This study corresponds to a monocentric prospective cohort of adult patients with systemic sclerosis.

It will allow the constitution of an organized collection of longitudinal clinical data as well as collection of biological samples, including blood samples, as well as stool sample and skin swab for microbiota analysis.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major patient with systemic sclerosis defined according to the EULAR 2013 criteria (see Appendix 1)
• Patient evaluated within the framework of the reference center for rare autoimmune diseases of the CHU of Brest.
• Patient affiliated to the social security system
• Patient having signed a written informed consent.

Exclusion criteria

• Minor
• Patient under legal protection (guardianship, curatorship)
• Refusal to participate
• Patient unable to consent
• Pregnant or breastfeeding woman
• Hemoglobin (Hb) level < 7g/dl

Trial design

100 participants in 1 patient group

Adults with systemic sclerosis

Description:

It is a descriptive cohort of systemic sclerosis patients

Treatment:

Other: Skin biopsies

Other: Skin swab samples

Other: Stool samples

Other: Blood samples

Other: Questionnaires on quality of life, pain and disability