ProspectIve Cohort psoriASiS fOllow-up (PICASSO)

Universitaire Ziekenhuizen KU Leuven

Status: Enrolling

Conditions: Psoriasis

Study type: Observational

Funder types: Other

Identifiers

NCT05122039

s64740

Details and patient eligibility

About

The main purpose of the PICASSO-project is to facilitate future psoriasis-research in dermatology. This register biobank will enable us to perform research in the field of metabolomics, mRNA-expression, cardiovascular impact and the microbiome. The final aims are patient stratification, better insight in disease-evolution and improved understanding of markers that predispose to severe disease.

Full description

The PICASSO-project is a prospective register with extensive biobanking in which patients with a recent onset of psoriasis (<3 years) can be enrolled. Participants are followed for a period of 10 years, with scheduled visits every 2.5 years. The same protocol is followed for every visit. The registry captures patient demographics, medical history (personal and family), details of psoriasis treatment (previous and current), physical examination, disease activity scores and PROMs. Some patients (substudy) will undergo ultra-sound to determine carotid intima media thickness. Biobanking in this project encompasses extensive biosampling of multiple tissues. It is not within the scope of this project to administer study medication: patients receive standard of care treatment as prescribed by their physician.

Enrollment: 200 estimated patients

Sex: All

Ages: 12 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical signs of Psoriasis since >3 years
• adults (70 years old or less) and children (>12 years old)
• willing and able to understand and sign the informed consent (plus legal representative in case of a minor)

Exclusion criteria

• unwilling or unable to understand and sign the informed consent
• disease duration longer than 3 years