Prospective Cohort Study of Association of Insulin Resistance/Steatosis With Hepatic Fibrosis in CHB and NAFLD

Seoul National University Boramae Hospital

Status: Completed

Conditions: Fatty Liver; Chronic Hepatitis B; Hepatic Fibrosis

Study type: Observational

Funder types: Other

Identifiers

NCT02031913

HBV_FL

Details and patient eligibility

About

Hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, clinical significance of steatosis and insulin resistance on fibrosis in chronic hepatitis B (CHB) is not well established. The aim was to investigate the relationship between insulin resistance, hepatic steatosis, and fibrosis in patients with CHB.

Full description

acoustic radiation force impulse elastography

Enrollment: 500 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic hepatitis B patients
• With evidences of hepatic steatosis on ultrasonography or pathology

Exclusion criteria

• significant alcohol consumption or other known liver diseases

Trial design

500 participants in 2 patient groups

HBV without FL

Description:

Chronic hepatitis B without steatosis

HBV with FL

Description:

Chronic hepatitis B patients with steatosis