Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

University of Southern California

Status: Completed

Conditions: Salmonella Infections; HIV Infections

Treatments: Drug: Amoxicillin trihydrate; Drug: Ceftriaxone sodium; Drug: Ampicillin sodium

Study type: Interventional

Funder types: Other

Identifiers

NCT00002052

019A

Details and patient eligibility

About

To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• Type I hypersensitivity to beta-lactam antibiotics.
• Not expected to survive 12 weeks.
• In a coma or with other central nervous system (CNS) impairment.

Patients with the following are excluded:

• Type I hypersensitivity to beta-lactam antibiotics.
• Not expected to survive 12 weeks.
• In a coma or with other central nervous system (CNS) impairment.

Prior Medication:

Excluded within 48 hours of study entry:

• Treatment with an antibiotic active in vitro against Salmonella.

HIV infection, AIDS, or AIDS related complex (ARC).

• Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.