Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy

Samsung Medical Center

Status: Completed

Conditions: Immunity

Study type: Observational

Funder types: Other

Identifiers

NCT00744159

IRB 2005-08-041

#CRS-106-14-1

Details and patient eligibility

About

This study aimed to clarify existence of immunological benefit of laparoscopic colon cancer surgery compared to open colon surgery.

Full description

Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host (total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the 5th day of operation (POD5).

Enrollment: 84 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Biopsy proven of colon cancer
• Preoperatively suspected as clinical stage III colon cancer
• Lesion located Descending colon, sigmoid colon and upper rectal cancer

Exclusion criteria

• Could not perform curative resection
• Intestinal obstruction, perforation, intra-abdominal abscess
• Severe medical illness
• Immunopathy

Trial design

84 participants in 2 patient groups

OC

Description:

Open colorectal resection

LC

Description:

Laparoscopic colorectal resection