Prospective Evaluation of Disparities in Provision of Allogeneic Transplantation

M.D. Anderson Cancer Center

Status: Enrolling

Conditions: Allogeneic Transplantation

Treatments: Behavioral: Patient Ancestry Questionnaires

Study type: Observational

Funder types: Other

Identifiers

NCT06450353

NCI-2024-04790 (Other Identifier)

2024-0253

Details and patient eligibility

About

To look at the effect of a recipient's ancestry and socio-economic status on their choice of bone marrow transplantation donor cells and their chance of receiving genetically similar (allogeneic) bone marrow cells versus cells that are not genetically similar (allograft).

Full description

Primary Objectives To prospectively evaluate graft options and choice of donor by patient ancestry and SES for allograft candidates at MDACC.

Secondary Objectives

• To prospectively evaluate time to transplant for allograft candidates at MDACC.
• To evaluate treatment-related mortality for allograft candidates at MDACC.
• To assess overall survival for allograft candidates at MDACC.
• To prospectively evaluate receipt of preferred unrelated donor for allograft recipients at MDACC.
• To evaluate receipt of an optimal graft for allograft recipients at MDACC.

Enrollment: 1,200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ≥ 18 years of age.
2. Candidate for allogeneic transplantation

Exclusion criteria

1) Allogeneic stem cell transplantation not medically indicated.

Trial design

1,200 participants in 1 patient group

Prospective evaluation

Description:

Participants are expected to be in this research study for up to 2 years after the participants bone marrow transplantation. However, your active participation will only last 1 day, when you sign the consent form and complete a questionnaire about your demographic information and ancestry (family ethnicity). For the rest of the study, information about the participants medical history, choice of bone marrow donor, and health outcomes will be collected from your medical record.

Treatment:

Behavioral: Patient Ancestry Questionnaires