Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement (Neurcog TAVR)

Baylor Scott and White Health (BSWH)

Status: Completed

Conditions: Mild Cognitive Impairment; Aortic Stenosis

Treatments: Other: 5 minute Montreal Cognitive Assessment (mini MoCA)

Study type: Observational

Funder types: Other

Identifiers

NCT05614986

021-262

Details and patient eligibility

About

This trail is for patients with mild cognitive impairment (MCI) who are receiving a transcatheter aortic valve replacement (TAVR). We will assess changes in neurocognition following TAVR with the 5 minute Montreal Cognitive Assessment (mini MoCA) when comparing pre procedure with post procedure assessments.

Full description

Patients with mild cognitive impairment who are being treated with a TAVR can choose to take part in this trial. This trial will prospectively enroll patients at 4 Baylor Scott & White facilities. 80 patients will be enrolled between all sites. The mini MoCA will be conducted at the following time points: pre TAVR, 30 days post TAVR, and 6 months post TAVR. All other data will be collected from patient charts and are considered standard part of their care.

Enrollment: 81 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 18 years or older

2. Undergoing a TAVR procedure

3. Possible MCI as determined by procedures already used in the TAVR clinics, including 1 of the 4:

   1. MMSE < 27
   2. History of MCI, dementia, or stroke (CVA or TIA)
   3. History of prescription treatment for MCI
   4. Discretion of the investigator, physician, or clinic staff

4. Scores 25 or less on the mini MoCA exam

Exclusion criteria

1. In another research study that doesn't allow dual enrolment, or dual enrolment has not been granted.

Trial design

81 participants in 1 patient group

Patients with Mild Cognitive Impairment Undergoing TAVR

Description:

Patients will be treated with standard of care. In addition, patients will complete the mini MoCA at 3 time points

Treatment:

Other: 5 minute Montreal Cognitive Assessment (mini MoCA)