Prospective Evaluation of Radiotherapy Using Magnetic Resonance Image Guided Treatment (PERMIT)

Institute of Cancer Research, United Kingdom

Status: Enrolling

Conditions: Cancer

Treatments: Device: MR Linac

Study type: Interventional

Funder types: Other

Identifiers

NCT03727698

CCR4841

Details and patient eligibility

About

The purpose of PERMIT is to collect information on the treatment of radiotherapy patients using a new radiotherapy machine that includes magnetic Resonance (MR) imaging (MR linac) to guide treatment. The aim is to use this information to support the introduction of MR Linac into clinical practice.

PERMIT will collect details on patients treated on the MR linac plus details on their side effects and other outcomes. This information plus technical and imaging information will be combined with information from other centres using this machine. By doing so this will help us learn how best to use the MR Linac in the future and design new radiotherapy protocols

Enrollment: 200 estimated patients

Sex: All

Ages: 5+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Radiotherapy treatment suitable to be delivered on the MR Linac.
2. Patient provides written, informed consent and/or authorization.
3. Patients between the ages of 5 and under 16 years old may enter protocol with parental/guardian consent.

Exclusion criteria

1. Contra-indications to MR imaging.
2. Radiotherapy not suitable for delivery on the MR Linac e.g. those with extended field lengths (exceeding 20 cm).

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 1 patient group

Radiotherapy delivered on the MR Linac

Experimental group

Description:

MR Guided radiotherapy treatment

Treatment:

Device: MR Linac