Prospective Evaluation of Taste Function In Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation

Memorial Sloan Kettering Cancer Center (MSK)

Status: Completed

Conditions: Multiple Myeloma

Treatments: Diagnostic Test: Comprehensive chemical gustometry; Diagnostic Test: Measurement of salivary flow; Diagnostic Test: Oral microbiota assessment; Behavioral: Surveys assessing taste disturbances

Study type: Observational

Funder types: Other

Identifiers

NCT03276481

17-404

Details and patient eligibility

About

The purpose of this study is to study taste disturbances on patients with myeloma who received high dose melphalan.

Enrollment: 47 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 21 or above with diagnosis of multiple myeloma (myeloma is almost unheard of in patients less than 21 years of age).
• Scheduled to receive conditioning chemotherapy with melphalan followed by upfront or salvage autologous peripheral blood hematopoietic stem cell transplantation
• English or Spanish speaking
• Calculated creatinine clearance > 40 mL/min

Exclusion criteria

• Prior head and neck radiation.
• Severe periodontal infection. Poor oral hygiene and dentition as determined by pre HCT dental assessment.
• Pregnancy
• Patients with pre-existing moderate-severe dysgeusia

Trial design

47 participants in 1 patient group

Multiple Myeloma

Description:

Participants with multiple myeloma undergoing autologous hematopoietic cell transplantation (HCT) after a high dose melphalan conditioning regimen

Treatment:

Behavioral: Surveys assessing taste disturbances

Diagnostic Test: Oral microbiota assessment

Diagnostic Test: Measurement of salivary flow

Diagnostic Test: Comprehensive chemical gustometry