Prospective Evaluation of the Preoperative Lymph Node Staging in Patients With Cancer of the Esophagogastric Junction and Stomach

University of Zurich (UZH)

Status and phase: Withdrawn; Phase 2

Conditions: Cancer of Esophagogastric Junction; Adenocarcinoma; Stomach Cancer

Treatments: Procedure: FDG-PET-CT

Study type: Interventional

Funder types: Other

Identifiers

NCT00800969

VIS-UGI-1

Details and patient eligibility

About

This prospective study includes patients with histologically proven cancer of the esophagogastric junction (Siewert Type II and III) and the stomach. Aim of the study is to evaluate the accuracy of PET-CT for the preoperative assessment of lymph node metastasis. The evaluation includes a combination with standard diagnostic tools (endoluminal ultrasound, CT and diagnostic laparoscopy prior to neoadjuvant therapy). Standardized D2-lymphadenectomy is performed and individual lymph node stations (Nr 1-12 according to the Japanese classification) are histopathologically examined. Furthermore we evaluate the role of the PET-CT for early metabolic response evaluation in patients receiving neoadjuvant chemotherapy.

• Trial with surgical intervention

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histological prove of adenocarcinoma of the stomach.

Exclusion criteria

• Recurrent gastric carcinoma
• No informed consent
• Previous malignancy (exception: thyroid, bladder in situ, Cervix in situ)

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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0 participants in 1 patient group

all patients

Other group

Description:

all patients with Adenocarcinoma

Treatment:

Procedure: FDG-PET-CT