Prospective Exploratory Cohort Study on Ganglion Cell Degeneration in Retinitis Pigmentosa Patients

University Medical Center Goettingen

Status: Invitation-only

Conditions: Retinitis Pigmentosa

Treatments: Diagnostic Test: imaging

Study type: Observational

Funder types: Other

Identifiers

NCT07056738

2025-03803

Details and patient eligibility

About

The aim of this study is an explorative prospective observation of retinal ganglion cell degeneration and/or inner retina degeneration in Retinitis pigmentosa patients. The rate and patterns of progression will be correlated to the outer retina layers as well as clinical and genetic data of patients. Secondary goal is to determine potential parameters for optogenetic treatment eligibility.

Enrollment: 130 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• genetically diagnosed Retintis pigmentosa
• minimum age of 18 years (legal adult age in Germany)
• patient consent for study participation

Exclusion criteria

• lack of capacity to consent in participation of study (unconsciousness, mental capacity, mental illness)
• reduced cooperation during imaging or examination
• age under 18 years
• presence of additional retinal diseases
• insufficient imaging quality due to hazy media (cornea, lense)