Prospective Follow-up After MVA-BN Booster Vaccination (POQS-Boosted)

Institute of Tropical Medicine, Belgium

Status: Not yet enrolling

Conditions: Monkeypox (Mpox)

Study type: Observational

Funder types: Other

Identifiers

NCT07342829

POQS-Boosted

Details and patient eligibility

About

POQS-Boosted is a prospective observational study during which individuals who received Booster vaccination against mpox with the MVA-BN vaccine will be invited to provide biological samples at multiple times over the course of two years.

Full description

Mpox caused a worldwide outbreak in 2022 and continues to circulate worldwide and causes sporadic cases in Belgium and elsewhere. In the last 10 days, the first cases infected with the probably more virulent clade Ib MPXV have been reported from men who have sex with men in Belgium, the Netherlands, and elsewhere, indicating circulating this viral clade in sexual networks. In Belgium, vaccination against mpox was ceased at the end of 2022 and evidence showed that antibody levels against MPXV have decreased since then, raising questions about sustained protectiveness and the potential for a new mpox outbreak to emerge.

POQS-Boosted is a prospective observational study during which individuals who received Booster vaccination against mpox with the MVA-BN vaccine will be invited to provide biological samples at multiple times over the course of two years.

Enrollment: 95 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Is scheduled to receive a booster dose of MVA-BN
2. ≥18 years
3. Willingness to provide written informed consent
4. Willingness to follow the study schedule

Exclusion criteria

1. Past or current MPXV infection