Prospective Genetic Study in Patients With Ovarian Insufficiency

The First Affiliated Hospital of Anhui Medical University

Status: Unknown

Conditions: Ovarian Dysgenesis; Diminished Ovarian Reserve; Primary Ovarian Insufficiency; Premature Ovarian Failure

Treatments: Procedure: IVF treatment

Study type: Observational

Funder types: Other

Identifiers

NCT03474120

Ovarian-Gene

Details and patient eligibility

About

genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.

Full description

The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment.

Enrollment: 300 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed as "premature ovarian insufficiency", "diminished ovarian reserve", "primary amenorrhea", " ovarian dysgenesis", " repeated implantation failure"

Exclusion criteria

• To rule out polycystic ovary syndrome（PCOS）, iatrogenic factors (such as surgery, radiotherapy and chemotherapy, etc.) lead to premature ovarian insufficiency in patients

Trial design

300 participants in 2 patient groups

IVF treatment group

Description:

Patients treated with IVF. IVF promotion process, ovulation, fertilization, embryo quality, transplantation and final outcome were collected after the treatment cycle was completed.

Treatment:

Procedure: IVF treatment

No IVF treatment group

Description:

the patients who did not have received IVF treatment .Patients were followed up to collect hormone levels, ultrasound results.