Prospective Genomics Initiative on Multiple Synchronous Lung Cancer (PGI-MSLC)

Shanghai Jiao Tong University

Status: Unknown

Conditions: Multiple Synchronous Lung Cancers (MSLCs)

Study type: Observational

Funder types: Other

Identifiers

NCT03795155

RenJiH-2018-056

Details and patient eligibility

About

This prospective study is to characterize the genomic landscape and genetic heterogeneity of multiple synchronous lung cancer (MSLC) in correlation with comprehensive clinical, histopathological and medical imaging information, in order to improve disease diagnosis and tailored treatment for MSLC patients.

Full description

• To initiate a prospective registry of MSLC patients with high-quality clinical samples and detailed medical data.
• To define the clonal relationship, genomic landscape and potential driver alterations of MSLC using whole-genome sequencing.
• To determine the intrapatient and intratumor genetic heterogeneity of MSLC.
• To correlate molecular features with clinical parameters and patient outcome.
• To serve as a continuous infrastructure for a large variety of research purposes including: A. Diagnostic research B. Prognostic research C. Biological research D. Interventional trial design testing new therapies in MSLC.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Confirmed diagnosis of multiple synchronous lung cancers (MSLCs) without metastatic disease
• Signed informed consent

Exclusion criteria

• Medical or psychiatric condition that would preclude informed consent
• History of known high-risk infections
• With metastatic tumors except lung