Prospective Investigation of Oxidative Stress in West Nile Virus Infection (PROWENI)

Institute of Tropical Medicine, Belgium

Status: Withdrawn

Conditions: West Nile Fever Meningoencephalitis; West Nile Virus Meningoencephalitis; West Nile Fever; West Nile Virus; West Nile Meningitis; West Nile Fever Meningitis; Oxidative Stress; West Nile Fever With Neurologic Manifestation; West Nile Fever Encephalitis

Study type: Observational

Funder types: Other

Identifiers

NCT04371003

ITM202005

Details and patient eligibility

About

The investigator hypothesizes that oxidative stress responses to West Nile virus infection in the central nervous system determine the severity of infection and the long-term neurological, neuropsychological and functional sequelae of West Nile Neuroinvasive Disease.

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Willing and able to provide written informed consent. If the clinical condition of the patient does not permit giving consent, informed consent will be obtained from the next of kin.
• Age 18 years or older
• for active cases: positive anti-WNV IGM antibodies in serum (or IgG in CSF if applicable)
• for active cases: presentation within (maximum) 7days of symptom onset
• for healthy controls: anti-WNV antibody naive (IgM and IgG in serum). The group of healthy controls will be selected to have an age similar distribution to the cases.

Exclusion criteria

• Evidence of active systemic infection in 3 months prior to recruitment
• Evidence of systemic inflammatory illness
• Clinical signs of neurodegenerative or neurologic disease other than WNND
• Pregnancy
• Active malignancy
• History of drug abuse

Trial design

0 participants in 3 patient groups

WNND

Description:

40 subject with West-Nile Neuroinvasive Disease will be recruited

WNF

Description:

40 subject with West-Nile Fever will be recruited

controls

Description:

20 control will be recruited. These controls will be aged matched to the cases.