Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis (ANTE-UP)

Laval University

Status: Completed

Conditions: Psychotic Disorders; Gambling Disorder

Treatments: Other: Psychiatric comorbidities; Drug: Antipsychotic use; Other: Gambling history; Other: Sociodemographics/socioeconomic status; Other: Clinical variables

Study type: Observational

Funder types: Other

Identifiers

NCT05686772

2020-OJUR-286304

Details and patient eligibility

About

The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis.

The main questions to be answered are:

1. What is the incidence of problem gambling in this population?
2. What are the predictors of problem gambling in this population?

To do so, putative predictors of problem gambling will be analyzed using Cox regression models:

• Sociodemographics (e.g., age, gender identity, ethnicity, level of education, employment);
• Psychiatric comorbidities (e.g., substance use disorders, cluster B personality disorders);
• Antipsychotic use (first/second-generation, third-generation [aripiprazole, brexpiprazole, cariprazine]);
• Prior gambling history.

Full description

All Cox regression models will be adjusted for site-effect. Further multivariable models will be constructed to examine the association between antipsychotic use (as continuous exposure) and incident PBG using the directed acyclic graphs approach to adjust for confounders.

Enrollment: 520 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 to 35 years old;
• Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features).

Exclusion criteria

• Active/prior PBG at te time of admission;
• Loss to follow-up within first three months;
• DSM-5 diagnosis of psychotic disorder due to a medical condition;
• Severe intellectual disability.

Trial design

520 participants in 1 patient group

First-episode psychosis patients

Description:

All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.

Treatment:

Other: Clinical variables

Other: Sociodemographics/socioeconomic status

Other: Gambling history

Drug: Antipsychotic use

Other: Psychiatric comorbidities