Prospective Observational Trial to Evaluate Quality of Life After Definitive Chemoradiation in Patients With Anal Cancer (LANACARE)

Ludwig Maximilian University of Munich

Status: Enrolling

Conditions: Anal Cancer; Quality of Life; Chemoradiation

Treatments: Other: EORTC QLQ CR29; Other: EORTC QLQ C30

Study type: Observational

Funder types: Other

Identifiers

NCT03792854

V1 10/2018

Details and patient eligibility

About

Observational study to evaluate longitudinal quality of life according to standardized EORTC questionaires as well as functional outcome, oncological outcome and toxicity in patients treated with definitive chemoradiation for anal cancer

Full description

Observational study to evaluate longitudinal quality of life according to standardized EORTC questionaires as well as functional outcome, oncological outcome and toxicity in patients treated with definitive chemoradiation for anal cancer. Qol will be evaluated by standardized EORTC questionaires QLQ C30 and QLQ CR29. Acute and late toxicity will be assessed according to CTCAE 4.03. Oncological outcome will be assessed with regard to local and distant control, patterns of recurrence, freedom from treatment failure and overall survival. Correlations of physicians- and patients-assessed functional outcomes are planned.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically proven anal cancer without distant metastases
• indication for definitive chemoradiation therapy based on multidisciplinary evaluation
• age >=18 years
• written informed consent
• ability to answer the standardized questionaires according to the treating physician

Exclusion criteria

• age < 18 years
• prior systemic therapy with regard to anal cancer
• distant metastases
• second malignancy