Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy

University of Colorado Denver (CU Denver)

Status: Invitation-only

Conditions: Craniopharyngioma, Child

Treatments: Procedure: Tumor and Blood Specimens

Study type: Observational

Funder types: Other

Identifiers

NCT03610906

14-0426.cc

Details and patient eligibility

About

New data suggests that the current treatment for pediatric adamantinomatous craniopharyngioma (CPA) may not be as effective as it could be.

Full description

Current treatment regimens for pediatric CPA are limited to surgery and radiation therapy. This pilot study seeks to identify biologically rational therapeutics for the medical treatment of adamantinomatous CPA by confirming the overexpression of specific molecules.

Enrollment: 250 estimated patients

Sex: All

Ages: 30 days to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients between 0-21 years of age.
2. Patients with the diagnosis or clinical suspicion of craniopharyngioma in whom planned clinical management will include tissue sampling.

Exclusion criteria

1. Patients in whom final pathology does not demonstrate adamantinomatous craniopharyngioma
2. Patients in whom tissue specimen is not obtained/available
3. Patients over 21 years of age.
4. Patients who choose not to participate

Trial design

250 participants in 1 patient group

Pediatrics with Tumors

Description:

Pediatrics who have a tumor specimen that is suspected to be craniopharyngioma, but is deemed superfluous to the clinical care of the patient (e.g. pathological diagnosis).

Treatment:

Procedure: Tumor and Blood Specimens