Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients (CAREBANK)

University of Turku

Status: Active, not recruiting

Conditions: Mitral Valve Disease; Cardiac Surgery; Coronary Artery Disease; Atrial Fibrillation; Aortic Valve Stenosis; Cardiac Tumor; Cardiac Arrythmias; Aortic Valve Disease

Treatments: Procedure: Cardiac surgery

Study type: Observational

Funder types: Other

Identifiers

NCT03444259

T273/2015

Details and patient eligibility

About

The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

Full description

The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.

Enrollment: 1,001 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any open-heart cardiac surgery
• Written informed consent
• All-comers design

Exclusion criteria

• No informed consent

Trial design

1,001 participants in 5 patient groups

Atrial fibrillation

Description:

Patients with atrial fibrillation

Treatment:

Procedure: Cardiac surgery

Coronary bypass

Description:

Patients undergoing coronary bypass

Treatment:

Procedure: Cardiac surgery

Aortic valve replacement

Description:

Patients undergoing aortic valve replacement

Treatment:

Procedure: Cardiac surgery

Mitral valve repair

Description:

Patients undergoing mitral valve repair

Treatment:

Procedure: Cardiac surgery

Other

Description:

Patients undergoing cardiac surgery for indication other than above

Treatment:

Procedure: Cardiac surgery