Prospective Randomized Trial of Laparoscopic Versus Open Liver Resection for HCC

Seoul National University

Status: Unknown

Conditions: Hepatocellular Carcinoma

Treatments: Procedure: Liver resection

Study type: Interventional

Funder types: Other

Identifiers

NCT00606385

SNUBH-GS-HBP1 (Other Identifier)

Details and patient eligibility

About

Short-term outcomes of laparoscopic liver resection is better than those of open liver resection

Laparoscopic liver resection is better than open resection in immunological aspects

Full description

Advantages and disadvantages of the laparoscopic compared with the open approach for liver resections

1. Advantages 1) Less postoperative ascites production 2) Reduced postoperative pain 3) Feasible in selected cirrhotics who have contraindications to open surgery 4) Less intra-abdominal adhesions (easier salvage transplantation) 5) Shorter recovery time 6) Shorter length of stay 7) Reduced financial cost
2. Disadvantages 1) No manual palpation or exploration of the liver parenchyma possible (with the pure laparoscopic approach) 2) High demand in surgical skill (especially major resections)

Enrollment: 84 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Radiologically diagnosed hepatocellular carcinoma
• Child classification A or B
• Aged 20 to 80
• Informed consent taken

Exclusion criteria

• Child classification C
• Extrahepatic metastasis
• Tumor located in central area or adjacent to middle hepatic vein
• Recurred hepatocellular carcinoma
• Critically ill patient
• Patient with psychiatric disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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84 participants in 2 patient groups

laparoscopic liver resection

Experimental group

Description:

Patients who underwent laparoscopic liver resection for HCC

Treatment:

Procedure: Liver resection

open liver resection

Active Comparator group

Description:

Patients who underwent open liver resection for HCC

Treatment:

Procedure: Liver resection