Prospective Studies of the Pathogenesis of Schizophrenia

University of North Carolina (UNC)

Status: Completed

Conditions: Schizophrenia

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00877552

R01HD053000-02 (U.S. NIH Grant/Contract)

P50MH064065-07 (U.S. NIH Grant/Contract)

04-1144

Details and patient eligibility

About

The purpose of this study is to use structural and functional magnetic resonance imaging (MRI) to study children at high risk for schizophrenia. It is hypothesized that children at high risk for schizophrenia will have abnormalities of brain development, especially of the cerebral cortex. The study will also describe normal brain development in children from birth to age 6 years

Full description

We are currently following enrolled children at 4 and 6 years of age. We are obtaining structural MRIs and rsfMRIs. In addition, we are assessing cognitive function and behavior with Stanford-Binet, BRIEF and BASC.

Enrollment: 598 patients

Sex: All

Ages: Under 6 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• control, offspring of mother with schizophrenia or bipolar illness; child with MVM

Exclusion criteria

• major neurological or medical illness

Trial design

598 participants in 4 patient groups

Control

Description:

Typically developing

Mild ventriculomegaly (MVM)

Description:

Fetal isolated mild ventriculomegaly

Schizophrenia High Risk

Description:

Offspring of mothers with schizophrenia

Bipolar High Risk

Description:

Offspring of mothers with schizophrenia