Prospective Studies of the Pathogenesis of Schizophrenia

University of North Carolina (UNC) logo

University of North Carolina (UNC)

Status

Completed

Conditions

Schizophrenia

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT00877552
R01HD053000-02 (U.S. NIH Grant/Contract)
P50MH064065-07 (U.S. NIH Grant/Contract)
04-1144

Details and patient eligibility

About

The purpose of this study is to use structural and functional magnetic resonance imaging (MRI) to study children at high risk for schizophrenia. It is hypothesized that children at high risk for schizophrenia will have abnormalities of brain development, especially of the cerebral cortex. The study will also describe normal brain development in children from birth to age 6 years

Full description

We are currently following enrolled children at 4 and 6 years of age. We are obtaining structural MRIs and rsfMRIs. In addition, we are assessing cognitive function and behavior with Stanford-Binet, BRIEF and BASC.

Enrollment

598 patients

Sex

All

Ages

Under 6 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • control, offspring of mother with schizophrenia or bipolar illness; child with MVM

Exclusion criteria

  • major neurological or medical illness

Trial design

598 participants in 4 patient groups

Control
Description:
Typically developing
Mild ventriculomegaly (MVM)
Description:
Fetal isolated mild ventriculomegaly
Schizophrenia High Risk
Description:
Offspring of mothers with schizophrenia
Bipolar High Risk
Description:
Offspring of mothers with schizophrenia

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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