Prospective Study In Noninvasive Evaluation of Hepatic Fibrosis in Chronic Hepatitis B

Peking University

Status: Completed

Conditions: Chronic Hepatitis B

Study type: Observational

Funder types: Other

Identifiers

NCT01679769

2012-455

81170386 (Other Grant/Funding Number)

Details and patient eligibility

About

The aim of our study is to evaluate liver fibrosis using biochemical markers, FibroScan, and radiology methods in patients with chronic hepatitis B in mainland China.

Full description

Up to Nov, 2015, total of 818 patients with chronic HBV infection had been enrolled in the study. Paired blood and liver biopsy specimen had been collected. The serum samples stored at -80 degree Celsius. All the liver biopsy samples were judged by three pathology experts, according to Ishak standard.

Enrollment: 818 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of chronic hepatitis B or compensated cirrhosis due to chronic hepatitis B virus infection
• agree to have liver biopsy

Exclusion criteria

• clinical diagnosis of decompensated cirrhosis due to hepatitis B virus or inactive carrier
• liver diseases due to other origin