Prospective Study of HIV Infection in Hemophiliacs

Bloodworks

Status: Completed

Conditions: Blood Disease; Blood Transfusion; Hepatitis, Viral, Human; Cytomegalovirus Infections; Hemophilia A; HIV Infections; Acquired Immunodeficiency Syndrome

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00005309

3012

R01HL043512 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.

Full description

BACKGROUND:

In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection.

DESIGN NARRATIVE:

Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored.

Sex: Male

Ages: Under 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

No eligibility criteria