Prospective Study of the Natural History of Patients With Type 2 and 3 Spinal Muscular Atrophy (NatHis-SMA)

Institut de Myologie, France

Status

Completed

Conditions

Type 3 Spinal Muscular Atrophy

Type 2 Spinal Muscular Atrophy

Treatments

Other: Muscle MRI

Other: Electrophysiology measurements

Other: Strength, function and activity measurements

Other: Blood sampling for biomarker analysis

Study type

Interventional

Funder types

Other

Identifiers

NCT02391831

IDRCB-2014-A01263-44 (Other Identifier)

NatHis-SMA

Details and patient eligibility

About

NatHis-SMA is a prospective, longitudinal and interventional study of the natural history of patients with type 2 and 3 Spinal Muscular Atrophy (SMA). The purpose of this study is to characterize the disease course over 2 years and identify prognostic variables of the disease and biomarkers of SMA progression, as well as determine the best outcome measures for further therapeutics approaches.

Enrollment

81 patients

Sex

All

Ages

2 to 30 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

INCLUSION CRITERIA

Type 2 or 3 spinal muscular atrophy genetically confirmed
Age superior or equal to 2 years old up to 30 years of age included
For patients older than 6 years old, willing and able to comply with all protocol requirements and procedures.
For non-ambulant patients, able to sit upright in a wheelchair for at least three hours
Patients over 18 years of age and parent(s)/legal guardian(s) of patients < 18 years of age must provide written informed consent prior to participating in the study and informed assent will be obtained from minors at least 7 years of age when required by regulation.
In France only: Affiliated to or a beneficiary of a social security category

EXCLUSION CRITERIA

Previously treated with an investigational drug within 6 months prior the recruitment in this study.
Other condition which may significantly interfere with the assessment of the SMA and is clearly not related to the disease
Current or anticipated participation in any therapeutic investigational clinical studies.
Patients with specific contraindication to MRI (i.e. metallic foreign body, claustrophobia, and others deemed to be prohibitive by the investigators) will be allowed to participate, but MRI will not be performed.
For women : pregnancy or current breastfeeding