Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia

University of Zurich (UZH)

Status: Completed

Conditions: Bronchopulmonary Dysplasia

Treatments: Other: blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT01644981

1.3 07.10.2011

Details and patient eligibility

About

Serial quantitative measurements of plasma pro-endothelin-1 concentrations in very preterm infants. Comparing pro-endothelin-1 with established clinical indices of bronchopulmonary dysplasia (BPD). Hypothesis: Pulmonary-vascular remodeling in infants developing BPD is directly related to circulating pro-endothelin-1, which therefore serves as surrogate marker of BPD.

Enrollment: 110 patients

Sex: All

Ages: 2 weeks to 4 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Very preterm infants born before 32 weeks gestational age

Exclusion criteria

• Severe fetal malformation, congenital heart defect, inborn syndrome, cardiomyopathy, fetal hydrops

Trial design

110 participants in 1 patient group

VLBW infants

Treatment:

Other: blood sampling