Prospective Trial of Autologous Platelet Rich Plasma in Aortic Surgery

Hongwen Ji

Status: Completed

Conditions: C.Surgical Procedure; Cardiac

Treatments: Device: Autologous Platelet-Rich Plasma Harvest Technique

Study type: Interventional

Funder types: Other

Identifiers

NCT02513862

2014-zx011

Details and patient eligibility

About

The purpose of this study is to determine whether autologous platelet rich plasma (APRP)is effective in reducing allogeneic blood transfusions during aortic surgery using deep hypothermic circulatory arrest.

Enrollment: 80 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing elective or emergency aortic surgery using deep hypothermic circulatory arrest、
• preoperative platelet counts>150000000000/L、
• preoperative hematocrit>33%、
• without recent anticoagulants less than 5 days

Exclusion criteria

• preoperative coagulation disorder
• severe renal and liver dysfunction
• preoperative hemodynamic instability

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

APRP group

Experimental group

Description:

APRP group is performed autologous platelet-rich plasma harvest technique before administration of heparin to the patient,the red blood cell(RBC) component is retransfused to the patient when the RBC transfusion protocol is reached,and the autologous platelet-rich plasma is transfused to the patient immediately after heparin is neutralized with protamine.

Treatment:

Device: Autologous Platelet-Rich Plasma Harvest Technique

control group

No Intervention group

Description:

APRP group receive no autologous platelet-rich plasma harvest technique.