Prospective Validation of 3D Dose Metrics as Selection Criteria for Adaptive Radiotherapy in Breast Cancer Patients

Maastricht Radiation Oncology

Status: Completed

Conditions: Breast Cancer

Treatments: Other: CBCT imaging

Study type: Observational

Funder types: Other

Identifiers

NCT03385031

P0268

Details and patient eligibility

About

In a retrospective study the investigators defined quantitative action levels based on dose and volume measures for adaptive radiation therapy in breast cancer patients (Zegers et al. Acta Oncol 2017). The aim of this study is to validate these parameters in a prospective study.

Full description

During radiotherapy, changes in patient anatomy or positioning can result into differences in dose deposition, which is the main factor influencing tumor control or side-effects. Dose-guided radiation therapy is the systematic evaluation of the dose delivery during treatment for an individual patient with the aim to adapt the treatment if needed. Recalculation of the dose during treatment can be performed using the imaging information during treatment. In a retrospective study the investigators defined quantitative action levels based on dose and volume measures for adaptive radiation therapy in breast cancer patients (Zegers et al. Acta Oncol 2017). The aim of this study is to validate these parameters in a prospective study.

Enrollment: 46 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Breast cancer patients
• Planned for external beam radiation treatment.
• Whole breast irradiation or Simultaneous integrated boost

Trial design

46 participants in 3 patient groups

group 1

Description:

whole breast irradiation, CBCT imaging at first and last fraction of radiotherapy treatment

Treatment:

Other: CBCT imaging

group 2

Description:

simultaneous integrated boost, CBCT imaging at first and last fraction of radiotherapy treatment

Treatment:

Other: CBCT imaging

group 3

Description:

patients with seroma at start radiation treatment (whole breast irradiation or simultaneous integrated boost), CBCT imaging at first and last fraction of radiotherapy treatment

Treatment:

Other: CBCT imaging