Prospective Validation of CARPET Prognostic Model for Septic Shock After Allo-HSCT

Peking University

Status: Not yet enrolling

Conditions: Stem Cell Transplant Complications

Treatments: Other: CARPET prognostic model

Study type: Observational

Funder types: Other

Identifiers

NCT06022445

PKUPH-model validation

Details and patient eligibility

About

Validation of CARPET prognostic model for septic shock after allo-HSCT: a multicenter, prospective, and cohort study

Full description

A clinical prognostic model named CARPET model for septic shock after allo-HSCT has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.

The equation of the prediction model for 28-day mortality was as follows:

Probability(28-day mortality)=(exp⁡(Y))/(1+exp⁡(Y)) where Y=2.343+1.328* Time of septic shock- 0.085* Albumin + 0.016 * Bilirubin-0.003*PaO2/FiO2 +0.127*Lactate- 0.011 * Glomerular filtration rate

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age >18 years
• underwent allo-HSCT
• diagnosed with septic shock

Exclusion criteria

• experienced septic shock before enrollment
• relapsed or progressed after HSCT

Trial design

200 participants in 1 patient group

Patients with septic shock after allo-HSCT

Description:

patients who underwent allo-HSCT and experienced septic shock

Treatment:

Other: CARPET prognostic model