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Prospective Validation of the CoDE-HF Algorithm for the Diagnosis of Acute Heart Failure (ProVa CoDE-HF)

U

University of Edinburgh

Status

Active, not recruiting

Conditions

Diagnosis
Acute Heart Failure

Treatments

Diagnostic Test: CoDE-HF decision support tool

Study type

Observational

Funder types

Other

Identifiers

NCT05518396
RE/18/5/34216 (Other Grant/Funding Number)
MRC/CIC8/79 (Other Grant/Funding Number)
DL-2021-003

Details and patient eligibility

About

Acute heart failure is a life-threatening condition where the heart is suddenly unable to pump blood around the body. It can be challenging to diagnose because the symptoms often mimic other conditions. Previous studies have showed that delays in making the correct diagnosis result in worse outcomes. We therefore developed a decision-support tool called CoDE-HF that uses a computer algorithm to combine levels of a blood test called NT-proBNP with patient factors to calculate the probability of acute heart failure for an individual.

In this project, we wish to evaluate the performance of CoDE-HF in approximately 2,000 patients attending the Emergency Department with suspected acute heart failure. We will store surplus material from their blood tests to measure NT-proBNP and link information from their electronic health records with other routinely collected medical information in regional and national databases in order to evaluate this algorithm.

Enrollment

3,808 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • Patients presenting to the Emergency Department with acute breathlessness

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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