Prostaglandin Analog Eyelash Serum and Ocular Surface Health: A Prospective Study (EYESERUM)

University of Seville

Status: Completed

Conditions: Dry Eye

Treatments: Other: Prostaglandin Analog-Based Eyelash Serum

Study type: Interventional

Funder types: Other

Identifiers

NCT06875687

USeville_2025_02

Details and patient eligibility

About

This prospective interventional study investigates the effects of a prostaglandin analog-based eyelash serum on ocular surface integrity, tear film stability, and eyelash growth over six weeks. Nineteen healthy female participants applied the serum daily, with clinical assessments performed at baseline and post-treatment. The study adhered to ethical guidelines, and parameters such as tear film stability, tear volume, ocular hyperemia, and eyelash characteristics were evaluated.

Enrollment: 19 patients

Sex: Female

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female individuals aged 18 to 30 years.
• Corrected distance visual acuity (CDVA) of 0.10 LogMAR or better in both eyes.
• Fitzpatrick skin type III or lower.
• No active dermatological conditions affecting the periocular area.
• Regular use of cosmetic products (e.g., mascara, eyeliner, or eyeshadow) with no history of intolerance.
• Willingness and ability to follow the serum application protocol for six weeks.

Exclusion criteria

• History or diagnosis of dry eye disease or other ocular surface disorders.
• Previous ocular surgery, trauma, or systemic conditions affecting ocular surface function.
• Use of topical or systemic medications that could impact tear film stability.
• Documented hypersensitivity or allergic reactions to cosmetic or ophthalmic products.
• Presence of eyelid disorders that could interfere with eyelash growth (e.g., blepharitis, trichiasis).
• Use of growth-enhancing serums within the past three months.
• Pregnancy or breastfeeding at the time of enrollment.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

Prostaglandin Analog-Based Eyelash Serum Group

Experimental group

Description:

This study arm consists of healthy female participants who applied a prostaglandin analog-based eyelash serum once daily to the upper eyelid margin for six weeks. The study evaluated changes in ocular surface integrity, tear film stability, and eyelash growth. Clinical assessments were performed at baseline and post-treatment, including measurements of tear film parameters, ocular hyperemia, and intraocular pressure.

Treatment:

Other: Prostaglandin Analog-Based Eyelash Serum