Prostaglandin E2 in Migraine Suffers Without Aura.

Troels Wienecke

Status: Completed

Conditions: "Migraine-like" Headache

Treatments: Drug: isoton sodium chloride; Drug: dinoprostone

Study type: Interventional

Funder types: Other

Identifiers

NCT01384812

DHC-PGE2-2011

Details and patient eligibility

About

The hypothesis of this study is that Prostaglandin E2 (PGE2) induces headache and dilatation of brain vessels in migraine patients without aura.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with migraine without aura

Exclusion criteria

• Tension type headache more than x 3 per month
• Other forms for primary headache
• Headache 24 h before the day of the investigation
• Migraine 48 h before the day of the investigation
• Hypertension
• Hypotension
• Pregnant/nursing
• Daily intake of medication (except oral contraceptives and migraine rescue medicine during migraine attack)
• Cardiovascular or central nervous system (CNS) disease
• Drug/alcohol abuse
• Psychiatric disease
• Asthma or any other lung diseases

Trial design

12 participants in 2 patient groups, including a placebo group

Isoton sodium chloride

Placebo Comparator group

Treatment:

Drug: isoton sodium chloride

Prostin E2 (dinoprostone)

Active Comparator group

Treatment:

Drug: dinoprostone