Prostasin Levels in Preeclamptic Women

Başakşehir Çam & Sakura City Hospital

Status: Completed

Conditions: Pre-Eclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT06623942

ProstasinStudy

Details and patient eligibility

About

This study will aim to compare maternal serum prostasin levels between women diagnosed with preeclampsia and healthy normotensive pregnant controls. Participants will be divided into two main groups: those with preeclampsia and those with uncomplicated pregnancies. The preeclampsia group will further be subdivided based on the severity of the condition. Maternal serum samples will be collected from all participants, and prostasin levels will be measured using ELISA. Statistical analyses will be performed to evaluate whether prostasin levels are significantly elevated in the preeclampsia group, particularly in those with severe features, and to assess its potential as a biomarker for the condition.

Enrollment: 88 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of Preeclampsia: Defined by new-onset hypertension (systolic Blood Pressure ≥140 mmHg and/or diastolic Blood Pressure ≥90 mmHg) after 20 weeks of gestation, with or without proteinuria.
• Control Group: Healthy pregnancies without preeclampsia or other significant maternal or fetal complications.

Exclusion criteria

• Multiple Pregnancies
• Pregestational Diabetes
• Chronic Hypertension
• Systemic Diseases (Chronic kidney disease, autoimmune diseases)
• Fetal Anomalies
• Premature Rupture of Membranes.

Trial design

88 participants in 2 patient groups

Group 1 (Control)

Description:

This group consists of uncomplicated pregnancies (who do not have pre-eclampsia or severe pre-eclampsia). These participants will be matched to the case group based on relevant characteristics such as age, gestational age, and other demographic factors.

Group 2 (Case - Pre-eclampsia)

Description:

This group consists of pregnant women diagnosed with pre-eclampsia and severe preeclampsia.