Prostate Cancer Screening and Dietary Heterocyclic Amines in African American Men

Lawrence Livermore National Laboratory at University of California

Status and phase: Unknown; Phase 2

Conditions: Prostate Cancer

Treatments: Other: physiologic testing; Procedure: study of high risk factors; Procedure: mutation carrier screening; Procedure: evaluation of cancer risk factors; Other: study of socioeconomic and demographic variables

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00354497

LLNL-05-104

CDR0000485428

Details and patient eligibility

About

RATIONALE: Screening may help doctors find prostate cancer sooner, when it may be easier to treat. The amount of heterocyclic amines in the diet may affect prostate cancer screening results and the risk of prostate cancer.

PURPOSE: This phase II trial is studying prostate cancer screening and dietary heterocyclic amines in African American men.

Full description

OBJECTIVES:

• Estimate dietary heterocyclic amine (HA) exposure in African American men who use HA-forming meats and cooking methods.
• Correlate dietary HA exposure with prostate-specific antigen and digital rectal exam screening results (i.e., higher HA exposure with increased abnormality in prostate cancer screening results) in these participants.

OUTLINE: This is a prospective study.

Participants complete a routine medical questionnaire and undergo a detailed dietary interview that focuses on meat consumption, cooking preferences, and other factors that may be associated with prostate cancer risk. Participants then undergo a digital rectal exam (DRE) and blood collection for prostate-specific antigen (PSA) testing (total PSA and % free PSA). Results of PSA testing and DRE, including follow-up instructions (if needed), are sent to the participant 3-4 weeks later.

Blood samples are also examined by phenotypic assays for UV-damage induced nucleotide excision-repair capacity.

PROJECTED ACCRUAL: A total of 800 participants will be accrued for this study.

Enrollment: 800 estimated patients

Sex: Male

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• African American male
• No previous diagnosis of prostate cancer
• Desires prostate cancer screening as a routine preventative medical service

PATIENT CHARACTERISTICS:

• Lives in or near Oakland, California
• Speaks English
• No medical or other disability (e.g., blindness, psychological dysfunction, or amputation) that would preclude study participation

PRIOR CONCURRENT THERAPY:

• Not specified