Protect - The Impact of a High Protein Diet on Preservation of Muscle Mass

Wageningen University

Status: Completed

Conditions: Obesity

Treatments: Other: High protein diet; Other: standard protein diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01915030

WM002-wp3

Details and patient eligibility

About

The present study is designed to investigate whether a high protein diet will preserve muscle mass during caloric restriction in older adults.

Enrollment: 61 patients

Sex: All

Ages: 55 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Overweight and obese subjects (BMI 27-40 kg/m2)
• Waist circumference male:≥ 102 cm, female: ≥ 88 cm
• Willingness and ability to comply with the protocol

Exclusion criteria

• Renal insufficiency
• Co-morbidities
• Type 1 & 2 diabetics (Fasting glucose level ≥ 7 mmol/L)
• Cancer
• COPD
• Participation in weight loss program 3 months before the intervention
• Participation of any heavy resistance-type exercise training (>1 wk) the last 2 y.
• Intentional or unintentional weight loss (> 3 kg in the last 3 months)
• Severe loss appetite
• Diagnosed allergy to milk products
• Gastric bypass
• Supplements or medication use for weight loss
• Participation in any other intervention trial
• Women can only participate if they are postmenopausal (last period ≥ a year ago)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

61 participants in 2 patient groups, including a placebo group

High protein diet

Experimental group

Description:

High protein diet during caloric restriction

Treatment:

Other: High protein diet

Standard protein diet

Placebo Comparator group

Description:

Standard protein diet during caloric restriction

Treatment:

Other: standard protein diet