Protection Against Benzene Toxicity

National Institutes of Health (NIH)

Status: Completed

Conditions: Aplastic Anemia; Leukemia

Study type: Observational

Funder types: NIH

Identifiers

NCT00011453

9554-CP-001

Details and patient eligibility

About

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.