Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty

Centro Medico Campinas

Status

Unknown

Conditions

Hemolysis

Treatments

Drug: Propofol

Study type

Interventional

Funder types

Other

Identifiers

NCT00792779

CAAE - 0023.0.263.000-08

Details and patient eligibility

About

The purpose of this study is to determine if propofol could protect erythrocytes by directly scavenging free radicals from the blood current and increasing resistance of their cell membranes in patients submitted to gastroplasty.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients between BMI 40-50 kg/m2

Exclusion criteria

patients with BMI under 40 kg/m2 and over 50 kg/m2
alcohol users
illicit-drug users
patients in regular use of anti-depressants, proton bomb inhibitors or calcium canal blockers
patients transfused either recently, during the intra-operative period or within 10 hours post-operative
patients previously known to be hypersensitive to any drug that is used during the study
patients with any psychiatric disorder or dementia