Protective Effects of Exercise Training (SOMEX)

Institute of Biomedical Research of the Army

Status: Completed

Conditions: Sleep Deprivation

Treatments: Other: Sleep deprivation

Study type: Interventional

Funder types: Other

Identifiers

NCT02820649

2014_A01103-44 (Other Identifier)

PDH-1-SMO-2-508

Details and patient eligibility

About

Rationale. Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction.

Objective. To determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men.

Methods: 16 subjects will be examined during 40-h TSD, both before and after 7 weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) as well as pulse wave velocity (PWV), blood pressure and heart rate (HR) will be assessed at baseline, during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00

Enrollment: 16 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Men
• 18 - 35 yrs

Exclusion criteria

• Consumming 400 mg of caffeine per day,
• Body mass index (BMI) greater than 30 kg/m²,
• Taking medication.
• Excessive daytime somnolence (Epworth Sleepiness Scale >9)
• Sleep complaints (Pittsburgh Sleep Quality Index >5)
• Inability to be considered as an intermediate chronotype on the Horne and Ostberg questionnaire (score <31 or >69)
• Traines subject (Ricci Gagnon questionnaire >35)

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

Exercise training

Experimental group

Description:

7 weeks of exercise training

Treatment:

Other: Sleep deprivation

Control

Sham Comparator group

Description:

Sedentary group

Treatment:

Other: Sleep deprivation