Protective Ventilation Based on Alveolar Ventilation in Children (PROVENTIPED)

Civil Hospices of Lyon

Status: Completed

Conditions: Peroperative Complication; Anesthesia

Treatments: Other: Alveolar ventilation monitoring estimated by the capnographic ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT03901599

69HCL19_0114

Details and patient eligibility

About

Protective ventilation decreased morbidity and mortality in adults' patients and is now a standard of care in intensive care unit and in anesthesiology. In children, there is no evidence in the literature to recommend protective ventilation during anaesthesia. Moreover the ratio of instrumental dead space to tidal volume is higher in children than in adults. Therefore, it is difficult to propose an "optimal" tidal volume for all children. The objective of this study is to evaluate the use of alveolar ventilation (estimated by the volumetric capnography) in children under anesthesia. The hypothesis is that in children, alveolar ventilation reported to ideal body weight is a constant to maintain normocarbia, unlike the tidal volume.

Enrollment: 60 patients

Sex: All

Ages: 2 months to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children aged < 12 and
• Weight between 5 and 40kg
• General anesthesia
• Non-opposition of parents or legal guardians

Exclusion criteria

• History of bronchodysplasia or laryngo tracheo malacia, cyanotic heart disease or neuromuscular disease
• Airleaks > 10%
• Bronchospasm during anesthesia

Trial design

60 participants in 3 patient groups

Children between 5-10Kg

Description:

Children with a body weight between 5-10Kg

Treatment:

Other: Alveolar ventilation monitoring estimated by the capnographic ventilation

Children between 10-20Kg

Description:

Children with a body weight between 10-20Kg

Treatment:

Other: Alveolar ventilation monitoring estimated by the capnographic ventilation

Children between 20-40Kg

Description:

Children with a body weight between 20-40Kg

Treatment:

Other: Alveolar ventilation monitoring estimated by the capnographic ventilation