Protective Ventilation Strategy

Seoul National University

Status: Completed

Conditions: One-lung Ventilation

Treatments: Other: ventilator setting during one-lung ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT03234621

JHBahk_PV

Details and patient eligibility

About

The purpose of this study is to find a proper ventilation strategy for one-lung ventilation to prevent postoperative pulmonary complications

Enrollment: 87 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing elective thoracic surgery
• ASA I, II, III
• scheduled > 2 hours of surgery

Exclusion criteria

• denied patients
• age under 18 years
• FEV1/FVC or FEV1<70% in preoperative pulmonary function test

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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87 participants in 3 patient groups

conventional tidal group

Experimental group

Description:

provide tidal volume of 6ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation

Treatment:

Other: ventilator setting during one-lung ventilation

low tidal group

Experimental group

Description:

provide tidal volume of 4ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation

Treatment:

Other: ventilator setting during one-lung ventilation

high tidal group

Experimental group

Description:

provide tidal volume of 8ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation

Treatment:

Other: ventilator setting during one-lung ventilation