Protein Expression in Human Neuroblastoma Tumor Samples

Children's Oncology Group

Status: Completed

Conditions: Neuroblastoma

Treatments: Genetic: protein expression analysis; Other: laboratory biomarker analysis; Genetic: western blotting

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01407731

NCI-2011-03799 (Registry Identifier)

ANBL11B4 (Other Identifier)

COG-ANBL11B4 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying protein expression in samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat neuroblastoma.

PURPOSE: This laboratory studying is looking at protein expression in tumor tissue samples from patients with neuroblastoma.

Full description

OBJECTIVES:

• To determine whether intersectin (ITSN1) proteins are present at elevated levels in primary human tumor samples.

OUTLINE: Archived tumor tissue samples are analyzed for intersectin (ITSN1) expression by western blot assays with enhanced chemiluminescence and exposed to X-ray film. The films are scanned, and levels of ITSN1 signal are quantified by densitometry.

Enrollment: 20 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosed with neuroblastoma
• Banked primary tumor samples from patients with stage 1, 2, 3, and 4 disease

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified