Protein Expression in Samples From Young Patients With Rhabdomyosarcoma

Children's Oncology Group

Status: Completed

Conditions: Sarcoma

Treatments: Genetic: protein expression analysis; Other: laboratory biomarker analysis; Other: immunohistochemistry staining method

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01426945

NCI-2011-03534 (Registry Identifier)

COG-ARST11B3 (Other Identifier)

ARST11B3 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.

Full description

OBJECTIVES:

• To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS) tumor samples.

OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.

Enrollment: 77 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Tumor tissue samples from children with rhabdomyosarcoma (RMS) enrolled in the Children's Oncology Group clinical trials

  • Alveolar rhabdomyosarcoma (ARMS)
  • Embryonal rhabdomyosarcoma (ERMS)

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified